Endocrine Abstracts

Introduction: The syndrome of inappropriate antidiuresis (SIAD) is the most common cause of euvolemic hyponatremia. Besides fluid restriction, increasing free water clearance is an effective treatment approach that can be achieved through osmotic diuresis by administering oral urea. Dietary proteins are metabolized into soluble excretable urea by the liver. We hypothesized that dietary protein could increase free water clearance through urea-induced osmotic diuresis and theref...

Background: The syndrome of inappropriate antidiuresis (SIAD) can be treated with oral urea. Proteins are metabolized into urea by the liver. We hypothesized that dietary protein could increase free water clearance through urea-induced osmotic diuresis.ObjectivesTo investigate the effect of protein supplementation on plasma sodium levels in chronic SIAD.Methods: This is a monocentric open-label proof-of-concept trial conducted at the University Hospital ...